[BS] Q.15) Factors Controlling Erythropoisis:

Ans. 

A. General factors:

1. Diet- Protein of high biological value which provides amino acid for synthesis of globin portion of Hb.
2. Hypoxia – It is a potent stimulus for RBC production. It stimulates release of erythropoietin hormone from kidneys ,which stimulates bone marrow for erythroposis.
3. Erythropoitin hormone.
4. Other hormone- such as Thyroxin which stimulate bone marrow for erythroposis.

B. Haemoglobinization factors:

1. Iron- Essential for heam formation of Hb.
2. Cu & Mg- Essential for conversion of iron into Hb by catalytic action.
3. Co- Influence activity of Cu & Mg & Globin synthesis.
4. Bile Salt- Helps proper absorption of vitamins & minerals.
5. Pb- Helps globing synthesis.

C. Maturation factors:

1. 1. Vit. B12- Acts as co-enzyme in DNA synthesis.
2. 2. Folic Acid – Acts as catalyst in DNA synthesis.
3. 3. Intrinsic factor of castle which helps in absorption of Vit. B12
4. 4. Riboflavin & necotinic acid- Heam synthesis.

                 Vit. C- Influence folic acid metabolism.